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579002

Sigma-Aldrich

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), solid, estrogen receptor modulator, Calbiochem

Sinónimos:

Tamoxifen, 4-Hydroxy-, (Z)-, (Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II

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About This Item

Fórmula empírica (notación de Hill):
C26H29NO2
Número de CAS:
68047-06-3
Peso molecular:
387.51
Número MDL:
MFCD00278780
Código UNSPSC:
12352200
NACRES:
NA.77

Nombre del producto

Tamoxifen, 4-Hydroxy-, (Z)-, A cell-permeable, active metabolite of Tamoxifen that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Nivel de calidad

200

Ensayo

≥99% (HPLC)

Formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze

color

white

solubilidad

methanol: 10 mg/mL
ethanol: 20 mg/mL (heating may be required)

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

InChI

1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

Clave InChI

DODQJNMQWMSYGS-QPLCGJKRSA-N

Descripción general

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: no

Advertencia

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Gundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Palabra de señalización

Danger

Frases de peligro

H302,H350,H360FD,H410

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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