579000

Tamoxifen Citrate

Tamoxifen is a potent synthetic anti-estrogenic agent.

• Sinónimos: Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I
• Fórmula empírica (notación de Hill): C₂₆H₂₉NO · xC₆H₈O₇
• Número de CAS: 54965-24-1
• Peso molecular: 371.51 (salt-free basis)
• MDL number: MFCD00058321
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: ethanol: 5 mg/mL; methanol: 5 mg/mL; water: sparingly soluble
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• InChI key: FQZYTYWMLGAPFJ-OQKDUQJOSA-N

Descripción

General description

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines.

A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 10 µM against protein kinase C

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H302,H350,H360D,H410
• pcodes: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable