565784-M

γ-Secretase Inhibitor IX

≥95% (HPLC), liquid, γ-secretase inhibitor, Calbiochem^®

• Sinónimos: InSolution γ-Secretase Inhibitor IX, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
• Fórmula empírica (notación de Hill): C₂₃H₂₆F₂N₂O₄
• Peso molecular: 432.46
• Código UNSPSC: 12352200

Propiedades

• Nombre del producto: γ-Secretase Inhibitor IX, InSolution, ≥95%, 25 mM, g-secretase Inhibitor IX
• Ensayo: ≥95% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: clear colorless
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC₅₀ = 115 nM; Aβ₄₂ IC₅₀ = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP₆₉₅. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.

Acciones bioquímicas o fisiológicas

Primary Target
Aβ_total

Target IC₅₀: 115 nM, 200 nM against Aβ_total, Aβ42, respectively

Advertencia

Toxicity: Irritant (B)

Forma física

A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.

Reconstitución

Following initial use, aliquot and freeze (-20°C).

Otras notas

Oddo, S., et al. 2004. Neuron43, 321.
Dovey, H.F., et al. 2001. J. Neurochem.76, 173.
Vandermeeren, M., et al. 2001. Neurosci. Lett.315, 145.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): 188.6 °F - closed cup - (refers to pure substance)
• Punto de inflamabilidad (°C): 87 °C - closed cup - (refers to pure substance)