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5291

Sigma-Aldrich

Polymyxin B Sulfate

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

Sinónimos:

Polymyxin B Sulfate, Aerosporin

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About This Item

Número de CAS:
1405-20-5
MDL number:
MFCD00131991
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

200

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

water: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

General description

Polymyxin B is a polypeptide antibacterial that belongs to the polymyxin family. It exerts its effects against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter sp., and Klebsiella sp.. Polymyxin B sulfate is a mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.

Application

Polymyxin B Sulfate - CAS 1405-20-5 – Calbiochem has been used:
  • to neutralize the endotoxins in bovine serum albumin
  • in the in vitro treatment of hepatic stellate cells (HSCs)
  • as an antibiotic in collateral sensitivity and cross-resistance analysis in Escherichia coli

Biochem/physiol Actions

Polymyxin B possesses antiendotoxin activity. It binds to lipid A of the lipopolysaccharide (LPS) molecules and facilitates penetration by displacing Ca2+ and Mg2+ in the outer membrane of Gram-negative bacteria.

Warning

Toxicity: Harmful (C)

Other Notes

Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Andrea Kwa et al.
Expert review of anti-infective therapy, 5(5), 811-821 (2007-10-05)
Hospital-acquired infections due to multidrug-resistant gram-negative bacteria constitute major health problems, since the medical community is continuously running out of available effective antibiotics and no new agents are in the pipeline. Polymyxins, a group of antibacterials that were discovered during
Guiqin Wu et al.
Cell chemical biology, 28(4), 524-536 (2021-01-13)
Aggregation can be selectively induced by aggregation-prone regions (APRs) contained in the target proteins. Aggregation-inducing antimicrobial peptides (Pept-ins) contain sequences homologous to APRs of target proteins and exert their bactericidal effect by causing aggregation of a large number of proteins.
Anna M Bischofberger et al.
Environmental microbiology, 22(7), 2664-2679 (2020-03-13)
Bacteria in nature often encounter non-antibiotic antibacterials (NAAs), such as disinfectants and heavy metals, and they can evolve resistance via mechanisms that are also involved in antibiotic resistance. Understanding whether susceptibility to different types of antibacterials is non-randomly associated across
Ivan Denisov et al.
Luminescence : the journal of biological and chemical luminescence, 33(6), 1054-1061 (2018-06-22)
In the present study, we demonstrate the use of a disposable luciferase-based microfluidic bioassay chip for environmental monitoring and methods for fabrication. The designed microfluidic system includes a chamber with immobilized enzymes of bioluminescent bacteria Photobacterium leiognathi and Vibrio fischeri
Yong Zou et al.
Cellular & molecular biology letters, 24, 5-5 (2019-03-02)
Tetrahydroxy stilbene glucoside (TSG) has been reported to exert a cytoprotective effect against various toxicants. However, the function and mechanism of TSG in palmitic acid (PA)-induced inflammation and apoptosis in cardiomyocytes are still unknown. The present study was designed to
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