287815

3,4-Dichloroisocoumarin

• Sinónimos: 3,4-Dichloroisocoumarin
• Fórmula empírica (notación de Hill): C₉H₄Cl₂O₂
• Número de CAS: 51050-59-0
• Peso molecular: 215.03
• Número MDL: MFCD00036960
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥99% (elemental analysis)
• Nivel de calidad: 100
• Formulario: lyophilized solid
• potencia: 5-100 μM IC₅₀
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated
• color: white
• solubilidad: DMF: 10 mM; DMSO: 10 mM
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Clc1[o][c](c2c(c1Cl)cccc2)=O
• InChI: 1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
• Clave InChI: SUGXUUGGLDCZKB-UHFFFAOYSA-N

Descripción

Descripción general

A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.

A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.

Effective concentration: 5-100 µM; t_½ = 20 min at pH 7.5.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
serine proteases

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Cain, K., et al. 1994. Biochem. Cell Biol.72, 631.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Harper, J.W., et al. 1985. Biochemistry24, 1831.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301,H315,H319,H335
• Consejos de prudencia: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable