251680

Dantrolene, Sodium Salt

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

• Sinónimos: Dantrolene, Sodium Salt
• Fórmula empírica (notación de Hill): C₁₄H₉N₄O₅ · Na
• Número de CAS: 14663-23-1
• Peso molecular: 336.23
• Número MDL: MFCD00079130
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• descripción: Merck USA index - 14, 2816
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: orange
• solubilidad: DMSO: 3 mg/mL; aqueous base: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• cadena SMILES: [Na]N1C(=O)N(CC1=O)\N=C\c2[o]c(cc2)c3ccc(cc3)[N+](=O)[O-]
• InChI: 1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
• Clave InChI: KSRLIXGNPXAZHD-HAZZGOGXSA-M

Descripción

Descripción general

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.

A skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
Ryanodine receptor

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Harmful (C)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3039.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable