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Key Documents

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D9175

Sigma-Aldrich

Dantrolene sodium salt

Sinónimos:

1-[(5-­(p-Nitro­phenyl)­fur­furyl­idene)­amino]­hydan­toin sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C14H9N4NaO5
Número de CAS:
14663-23-1
Peso molecular:
336.23
MDL number:
MFCD00079130
UNSPSC Code:
12352200
PubChem Substance ID:
24278823
NACRES:
NA.77

form

solid

Quality Level

200

originator

JHP Pharmaceuticals

SMILES string

[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChI key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

Gene Information

human ... RYR1(6261) , RYR3(6263)

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Biochem/physiol Actions

Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.

Features and Benefits

This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by JHP Pharmaceuticals. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Beth A McNally et al.
Frontiers in physiology, 12, 737291-737291 (2021-10-16)
Daily regulation of Ca2+ - and voltage-activated BK K+ channel activity is required for action potential rhythmicity in the suprachiasmatic nucleus (SCN) of the hypothalamus, the brain's circadian clock. In SCN neurons, BK activation is dependent upon multiple types of
Mohammed Ali Azam et al.
Heart rhythm O2, 2(6Part B), 733-741 (2022-01-07)
Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics
Pedro Xavier Royero et al.
Experimental neurology, 327, 113213-113213 (2020-01-29)
Status epilepticus (SE) is a clinical emergency that can lead to the development of temporal lobe epilepsy (TLE). The development and maintenance of spontaneous seizures in TLE are linked to calcium (Ca+2)-dependent processes such as neuronal cell loss and pathological
Jiao Liu et al.
Frontiers in pharmacology, 13, 882198-882198 (2022-05-07)
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly
Z H Németh et al.
Brain research bulletin, 46(3), 257-261 (1998-07-17)
Recent studies suggested that transmitters released from the sympathetic nerve terminals can modulate various inflammatory responses by occupation of receptors on immune cells. These neurotransmitters act via alteration of intracellular concentration of second messengers. For instance, intracellular calcium as a
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