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D-013

Supelco

Dextromethorphan solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C18H25NO
Número de CAS:
125-71-3
Peso molecular:
271.40
MDL number:
MFCD00866833
UNSPSC Code:
41116107
PubChem Substance ID:
329798586
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1

InChI

1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1

InChI key

MKXZASYAUGDDCJ-NJAFHUGGSA-N

Gene Information

human ... GRIN2A(2903) , SIGMAR1(10280)

General description

Dextromethorphan is an opiate analgesic sold as an antitussive under trade names such as Robitussin®, NyQuil®, or Dimetapp®. Also known as DXM, the drug is used recreationally as a hallucinogen with effects similar to ketamine and phencyclidine (PCP). This Certified Snap-N-Spike® Solution is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to P450 trials and pharmaceutical research.

Application


  • Voriconazole-D3 isotopic label: It is used to develop a method for the simultaneous determination of voriconazole and its metabolite, voriconazole N-oxide, in human urine using liquid chromatography/tandem mass spectrometry. This study highlights the application of voriconazole-D3 as a stable isotope-labeled internal standard, crucial for accurate quantification and monitoring of drug metabolism in clinical pharmacokinetic studies (Yu et al., 2022).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dimetapp is a registered trademark of Wyeth LLC
NyQuil is a registered trademark of Procter & Gamble Co.
Robitussin is a registered trademark of Wyeth LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11.0 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in which the pathophysiological mechanisms of the pain and hypersensitivity are incompletely understood. IBS patients frequently complain of pain in body regions somatotopically distinct from the gut, suggesting involvement of central
Andreas Trojan et al.
Cancer chemotherapy and pharmacology, 71(2), 301-306 (2012-10-27)
Endoxifen serum concentrations seem to correlate with outcome in breast cancer (BC) patients. Concurrently, cytochrome P450 2D6 (CYP2D6) enzyme activity and dextromethorphan (DM) metabolism are deemed a surrogate marker for the formation of endoxifen. Here, we conducted a matched cohort
Shiou-Lan Chen et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7(4), 1025-1033 (2012-09-20)
Recent studies show that proinflammatory cytokines might be related to the development of opioid dependence (physiological, psychological, or both). In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids
F L Opdam et al.
Cancer chemotherapy and pharmacology, 71(3), 593-601 (2012-12-12)
Adjuvant therapy with tamoxifen significantly reduces breast cancer recurrence and mortality in estrogen receptor positive disease. CYP2D6 is the main enzyme involved in the activation of the prodrug tamoxifen into the anti-estrogen endoxifen. Endoxifen is thought to be a main
Shinn-Jong Jiang et al.
Microcirculation (New York, N.Y. : 1994), 20(2), 190-201 (2012-11-13)
This study examines the effect of Dextromethorphan (d-3-methoxy-17-methylmorphinan; DXM), a commonly used cough-suppressing drug, on the expression of VCAM-1 and ICAM-1 in human umbilical vein endothelial cells (HUVECs) stimulated with lipopolysaccharide (LPS). The effect of DXM on expression of cell
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