910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• Sinónimos: Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• Fórmula empírica (notación de Hill): C₁₂H₂₃N₃O₇
• Número de CAS: 217180-81-9
• Peso molecular: 321.33
• Número MDL: MFCD31561141
• Código UNSPSC: 12352106

Propiedades

• Ensayo: ≥95%
• Formulario: (Liquid or Semi-solid or Paste or Solid)
• idoneidad de la reacción: reaction type: click chemistry; reagent type: cross-linking reagent
• grupo funcional: azide; carboxylic acid
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Otras notas

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable