902683

BocNH-PEG5-acid

• Sinónimos: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH₂COOH
• Fórmula empírica (notación de Hill): C₁₇H₃₃NO₉
• Número de CAS: 890152-41-7
• Peso molecular: 395.45
• UNSPSC Code: 12352106
• NACRES: NA.22

Propiedades

• form: liquid
• reaction suitability: reaction type: Pegylations; reagent type: cross-linking reagent
• functional group: Boc; amine; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Descripción

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable