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850993

Sigma-Aldrich

2-Aminoisobutyic acid

98%, for peptide synthesis

Sinónimos:

α-Aminoisobutyric acid, 2-Methylalanine, Aib

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About This Item

Fórmula lineal:
(CH3)2C(NH2)COOH
Número de CAS:
62-57-7
Peso molecular:
103.12
Beilstein/REAXYS Number:
506496
EC Number:
200-544-0
MDL number:
MFCD00008049
UNSPSC Code:
12352106
PubChem Substance ID:
24888304
NACRES:
NA.22

product name

2-Aminoisobutyic acid, 98%

Quality Level

200

assay

98%

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

mp

≥300 °C

application(s)

peptide synthesis

SMILES string

CC(C)(N)C(O)=O

InChI

1S/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7)

InChI key

FUOOLUPWFVMBKG-UHFFFAOYSA-N

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General description

2-Aminoisobutyric acid also known as α-aminobutyric acid, is an amino acid used in solution-phase peptide synthesis. It is a desirable building block for peptides because of its strong tendency to cause the peptide to form a helical shape.

Application

2-Aminoisobutyric acid can be used to synthesize self-assembled polypeptide nanoparticles. Incorporation of this compound into the peptide chain can prevent undesired reactions since it is di-α-substituted, and inert to C−H abstraction.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCBS6869V
BCCK7155
BCBH0667V
BCBC6917V
BCBC6917

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Photochemical methods for peptide macrocyclisation
Chemistry?A European Journal , 27, 69-88 (2021)
Amphiphilic polypeptides with prolonged enzymatic stability for the preparation of self-assembled nanobiomaterials
Royal Society of Chemistry Advances, 8, 34603-34613 (2018)
Yutong Yang et al.
Membranes, 10(11) (2020-11-14)
Amine-containing mixed-matrix membranes incorporated with amino-functionalized multi-walled carbon nanotubes (AF-MWNTs) were synthesized for CO2/H2 separation based on the facilitated transport mechanism. AF-MWNTs were chosen primarily as the mechanical reinforcing filler to enhance the membrane stability. At 107 °C and 0.2-MPa
C Lucarelli et al.
Journal of chromatography, 541(1-2), 285-296 (1991-03-22)
A procedure is described for the determination of alpha-methyldopa (MD) [L-3-(3,4-dihydroxyphenyl)-2-methylalanine], its metabolite and catecholamines in the urine and plasma of patients undergoing MD therapy, by high-performance liquid chromatography with dual working electrode coulometric detection. An efficient sample preparation procedure
Oak Z Chi et al.
Anesthesia and analgesia, 110(5), 1412-1418 (2010-03-23)
We performed experiments to test whether isoflurane pretreatment produces vascular effects, especially at the levels of arterioles and capillaries affecting regional cerebral blood flow (rCBF), O(2) supply and consumption, or capillary permeability in focal cerebral ischemia. Because inducible nitric oxide
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