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347795

Sigma-Aldrich

Sodium dichloroacetate

98%

Sinónimos:

Dichloroacetic acid sodium salt

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About This Item

Fórmula lineal:
Cl2CHCO2Na
Número de CAS:
2156-56-1
Peso molecular:
150.92
Número CE:
218-461-3
Número MDL:
MFCD00070489
Código UNSPSC:
12352302
ID de la sustancia en PubChem:
24861527
NACRES:
NA.22

grado

for analytical purposes

Ensayo

98%

impurezas

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

grupo funcional

chloro

cadena SMILES

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

Clave InChI

LUPNKHXLFSSUGS-UHFFFAOYSA-M

Información sobre el gen

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

Descripción general

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Aplicación

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335,H351

Clasificaciones de peligro

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCM4560
BCCL3379
BCCK3450
STBK2573
STBK0770

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Case report: sodium dichloroacetate (DCA) inhibition of the ?Warburg Effect? in a human cancer patient: complete response in non-Hodgkin?s lymphoma after disease progression with rituximab-CHOP.
Strum SB., et al.
Journal of Bioenergetics and Biomembranes, 45(3), 307-315 (2013)
Yongchong Yang et al.
European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). In this paper, a variety of DCA derivatives were synthesized, and
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
Peng Wang et al.
Shock (Augusta, Ga.), 49(6), 704-711 (2017-08-29)
No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates pyruvate dehydrogenase (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of pyruvate
Frank Comhaire
Medical hypotheses, 120, 65-67 (2018-09-18)
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably
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