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Sigma-Aldrich

4-Diphenylmethoxy-1-methylpiperidine hydrochloride

95%

Sinónimos:

4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C19H23NO · HCl
Número de CAS:
132-18-3
Peso molecular:
317.85
EC Number:
205-049-3
MDL number:
MFCD00012835
UNSPSC Code:
12352100
PubChem Substance ID:
24856946
NACRES:
NA.22

Quality Level

100

assay

95%

mp

203-205 °C (lit.)

functional group

ether
phenyl

SMILES string

Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3

InChI

1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H

InChI key

LPRLDRXGWKXRMQ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Categorías relacionadas

General description

4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.

Application

4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
05910AJ
08403AJ
04131AM
01828TT

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T Ohno et al.
Journal of the neurological sciences, 182(2), 95-97 (2001-01-04)
A long-term follow-up study was made of three patients with cerebrotendinous xanthomatosis (CTX) associated with parkinsonism, two of whom were siblings. Besides typical CTX symptoms, all three patients showed severe parkinsonism. This observation has been rarely reported in CTX. The
Gennady B Lapa et al.
European journal of pharmacology, 506(3), 237-240 (2005-01-04)
Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse
N Shibata et al.
Rinsho shinkeigaku = Clinical neurology, 30(9), 978-984 (1990-09-01)
Two sibling cases of cerebrotendinous xanthomatosis with parkinsonism were reported. One was a woman of 39 years old, and another was her sister of 36 years old. In both cases, febrile convulsion appeared on 1.5 year old, and mental deterioration
M Vasudevan et al.
Journal of pharmaceutical and biomedical analysis, 24(1), 25-31 (2000-12-07)
A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH
M A Lung et al.
Rhinology, 25(2), 95-100 (1987-06-01)
The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses
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