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226351

Sigma-Aldrich

N-Hydroxymaleimide

97%, for peptide synthesis

Sinónimos:

1-Hydroxypyrrole-2,5-dione

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About This Item

Fórmula empírica (notación de Hill):
C4H3NO3
Número de CAS:
4814-74-8
Peso molecular:
113.07
Beilstein/REAXYS Number:
1524594
EC Number:
225-385-4
MDL number:
MFCD00005501
UNSPSC Code:
12352005
PubChem Substance ID:
24853562
NACRES:
NA.22

product name

N-Hydroxymaleimide, 97%

assay

97%

form

solid

reaction suitability

reaction type: Addition Reactions

mp

130-133 °C (dec.) (lit.)

application(s)

peptide synthesis

functional group

imide
maleimide

SMILES string

ON1C(=O)C=CC1=O

InChI

1S/C4H3NO3/c6-3-1-2-4(7)5(3)8/h1-2,8H

InChI key

BUXKULRFRATXSI-UHFFFAOYSA-N

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General description

N-Hydroxymaleimide (NHMI) is an organic compound that is widely used as an oxidizing agent in organic synthesis. It is frequently used to selectively oxidize thiols to disulfides and in the synthesis of α, β-unsaturated carbonyl compounds. It can also act as a Michael acceptor and is used in the synthesis of peptides and proteins.

Application

N-Hydroxymaleimide can be used as an oxidant to generate N-hydroxy anilines in situ, which serve as key intermediates in the selective coupling reaction of N-substituted anilines with hydroxylamine derivatives, for the efficient synthesis of aromatic oximes.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCC3003
BCBW0273
BCBH2786V
1451856V
1451856

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