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UC263

Sigma-Aldrich

7-Hydroxycoumarin glucuronide sodium salt

Sinónimos:

7-Hydroxy-2H-1-benzopyran-2-one glucuronide sodium salt, Umbelliferone glucuronide sodium salt

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About This Item

Fórmula empírica (notación de Hill):
C15H13NaO9
Número de CAS:
66695-14-5
Peso molecular:
360.25
MDL number:
MFCD00674902
UNSPSC Code:
12161501
PubChem Substance ID:
24724651
NACRES:
NA.77

form

solid

color

white to faint yellow

mp

≥285 °C

storage temp.

2-8°C

SMILES string

[Na+].O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C([O-])=O)Oc2ccc3C=CC(=O)Oc3c2

InChI

1S/C15H14O9.Na/c16-9-4-2-6-1-3-7(5-8(6)23-9)22-15-12(19)10(17)11(18)13(24-15)14(20)21;/h1-5,10-13,15,17-19H,(H,20,21);/q;+1/p-1/t10-,11-,12+,13-,15+;/m0./s1

InChI key

SKHLGBDGEPDEME-KSOKONAESA-M

Application

7-Hydroxycoumarin glucuronide sodium salt can be used as a standard for the analysis of 7-hydroxycoumarin metabolites.
Phase II (UDP-GT) metabolite of 7-hydroxycoumarin.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Hanneke G M Wittgen et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(6), 1076-1079 (2012-03-15)
Coumarin (1,2-benzopyrone) is a natural compound that has been used as a fragrance in the food and perfume industry and could have therapeutic usefulness in the treatment of lymphedema and different types of cancer. Several previous pharmacokinetic studies of coumarin
D P Bogan et al.
Journal of capillary electrophoresis, 2(5), 241-245 (1995-09-01)
An assay utilizing CE, has been developed for studying the in vitro metabolism of 7-hydroxycoumarin to 7-hydroxycoumarin-glucuronide. A reaction mixture containing a crude preparation of bovine uridine diphosphate (UDP) glucuronyl transferase (UDPGT) and the substrates uridine diphosphate glucuronic acid (UDPGA)
T J Hardt et al.
Arzneimittel-Forschung, 33(10), 1442-1446 (1983-01-01)
Blood concentration-time data of coumarin (C), 7-hydroxycoumarin (7-HC) and 7-hydroxycoumarin glucuronide (7-HCG) were obtained in rats receiving intraperitoneal doses of C ranging from 2.5 to 60 mg/kg and of 7-HC ranging from 2.5 to 20 mg/kg. Coumarin blood levels were
D L Hiller et al.
Analytical biochemistry, 227(1), 251-254 (1995-05-01)
An improved HPLC method for the analysis of 7-ethoxycoumarin and its metabolites in liver-slice incubation media is presented. The assay is based on short-column gradient elution which permits baseline resolution of the parent drug and three metabolites with a fourfold
U S Weber et al.
Research communications in molecular pathology and pharmacology, 99(2), 193-206 (1998-05-16)
Coumarin is found in many medicinal plants and therefore also used in phytomedicine for the treatment of venous diseases. The metabolic pathways of coumarin in the human body lead to the intermediate 7-hydroxy-coumarin and consequent glucuronidation in the intestine and
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