B102

Bupropion hydrochloride

≥98% (HPLC), solid, dopamine and norepinephrine transporter inhibitor

• Sinónimos: (±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
• Fórmula empírica (notación de Hill): C₁₃H₁₈ClNO · HCl
• Número de CAS: 31677-93-7
• Peso molecular: 276.20
• Número CE: 250-759-9
• Número MDL: MFCD00055209
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24277884
• NACRES: NA.77

Propiedades

• Nombre del producto: Bupropion hydrochloride, ≥98% (HPLC), solid
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• color: white
• solubilidad: H₂O: 15 mg/mL, clear
• emisor: GlaxoSmithKline
• cadena SMILES: Cl[H].CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1
• InChI: 1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
• Clave InChI: HEYVINCGKDONRU-UHFFFAOYSA-N
• Información sobre el gen: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , SLC6A2(6530) , SLC6A3(6531)

Descripción

Descripción general

Bupropion is structurally linked to the phenylethylamine family. It is a monocyclic aminoketone (chloropropiophenone).[1]

Aplicación

Bupropion hydrochloride has been used as an anti-depressant and injected into mice intraperitoneally for forced swim test.[2] It has also been used to study its effects on depression, anxiety and smoking cessation.[1]

Acciones bioquímicas o fisiológicas

Bupropion possesses antidepressant and anxiolytic properties. It serves as a good auxiliary for people who makes an effort to give up smoking. It may also be used in the treatment for attention-deficit hyperactivity disorder.[1]

Inhibits the dopamine and norepinephrine transporters with K_is of 2.8 μM and 1.4 μM, respectively. Does not inhibit the serotonin transporter (K_i = 45 μM). Antidepressant.

Características y beneficios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Faceshields, Gloves