T2879

Tyramine hydrochloride

≥98% (TLC), powder, neuromodulator

• Sinónimos: 4-(2-Aminoethyl)phenol hydrochloride, 4-Hydroxyphenethylamine hydrochloride, Tyrosamine hydrochloride
• Fórmula lineal: HOC₆H₄CH₂CH₂NH₂ · HCl
• Número de CAS: 60-19-5
• Peso molecular: 173.64
• Beilstein: 3627058
• Número CE: 200-462-5
• Número MDL: MFCD00012901
• Código UNSPSC: 12352116
• ID de la sustancia en PubChem: 24277896
• NACRES: NA.77

Propiedades

• Nombre del producto: Tyramine hydrochloride, ≥98%
• Nivel de calidad: 200
• Ensayo: ≥98%
• mp: 271-274 °C (lit.)
• solubilidad: H₂O: soluble 50 mg/ml, clear, colorless to faintly yellow
• cadena SMILES: Cl[H].NCCc1ccc(O)cc1
• InChI: 1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H
• Clave InChI: RNISDHSYKZAWOK-UHFFFAOYSA-N
• Información sobre el gen: human ... ADORA2A(135) , ADORA2B(136) , ADORA3(140)

Descripción

Aplicación

Tyramine hydrochloride has been:

• coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure[1]
• labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis[2]
• used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification[3]

Acciones bioquímicas o fisiológicas

Can enter catecholaminergic terminals and be released as a false transmitter.

Tyramine is a biogenic amine and a neuromodulator[4] localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders.[5] Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.[6]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves