SML1629

Ezetimibe

≥98% (HPLC)

• Sinónimos: (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
• Fórmula empírica (notación de Hill): C₂₄H₂₁F₂NO₃
• Número de CAS: 163222-33-1
• Peso molecular: 409.43
• MDL number: MFCD00937872
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825513
• NACRES: NA.77

Propiedades

• Quality Level: 200
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMF: soluble ≥15 mg/mL; DMSO: soluble ≥15 mg/mL; ethanol: soluble ≥15 mg/mL; methanol: soluble ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O
• InChI: 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
• InChI key: OLNTVTPDXPETLC-XPWALMASSA-N

Descripción

Biochem/physiol Actions

Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen.

Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations.

Reconstitution

For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable