SML0842

CRANAD 2

≥98% (HPLC)

• Sinónimos: (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron
• Fórmula empírica (notación de Hill): C₂₃H₂₅BF₂N₂O₂
• Número de CAS: 1193447-34-5
• Peso molecular: 410.26
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: , dark blue to black
• solubility: DMSO: 0.2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• InChI: 1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+
• InChI key: PVXQJYXODFZTBR-KAVGSWPWSA-N

Descripción

Biochem/physiol Actions

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, CRANAD 2 exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD 2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable