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Merck
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Key Documents

SML0674

Sigma-Aldrich

Ramosetron hydrochloride

≥98% (HPLC)

Sinónimos:

(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060

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About This Item

Fórmula empírica (notación de Hill):
C17H17N3O · HCl
Número de CAS:
132907-72-3
Peso molecular:
315.80
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -36 to -46°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

InChI

1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

InChI key

XIXYTCLDXQRHJO-RFVHGSKJSA-N

Biochem/physiol Actions

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Jung-Hee Ryu et al.
International journal of surgery (London, England), 11(2), 183-187 (2013-01-15)
Up to 75% of the patients undergoing laparoscopic cholecystectomy develop postoperative nausea and vomiting (PONV). Both ramosetron, a serotonin subtype 3 (5-HT3) antagonist, and dexamethasone are effective for PONV prophylaxis following laparoscopic cholecystectomy but their combined effect has not been
D K Choi et al.
Acta anaesthesiologica Scandinavica, 54(8), 962-969 (2010-07-16)
The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. A total of 320 patients scheduled for elective cardiac
Postoperative Nausea and Vomiting, 58-58 (2016)
A new antiemetic ramosetron hydrochloride
Tsukagoshi S
Gan to Kagaku Ryoho. Cancer & Chemotherapy, 24(3), 371-380 (2016)
Yoshitaka Fujii
Current drug safety, 6(2), 122-127 (2011-03-09)
Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events of anesthesia and surgery. Serotonin receptor antagonists (SRAs), including ondansetron, granisetron, tropisetron, dolasetron, and ramosetron, effectively decrease the incidence of PONV. Among these SRAs, ramosetron is the most effective
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