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SML0003

Sigma-Aldrich

CID755673

≥98% (HPLC), powder

Sinónimos:

2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one, 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one

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About This Item

Fórmula empírica (notación de Hill):
C12H11NO3
Número de CAS:
521937-07-5
Peso molecular:
217.22
Número MDL:
MFCD03828155
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825080
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

powder

color

white to tan

solubilidad

DMSO: ≥15 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Oc1ccc2oc3C(=O)NCCCc3c2c1

InChI

1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)

Clave InChI

AACFPJSJOWQNBN-UHFFFAOYSA-N

Categorías relacionadas

Aplicación

CID755673 was used to study the role of PKD in dendrite retraction in mouse Purkinje cells.

Acciones bioquímicas o fisiológicas

CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1 (PKCμ), PKD2, and PKD3 (PKCν). CID755673 is not competitive with ATP.
CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1(PKCμ), PKD2, and PKD3 (PKCν).
CID755673 was not suitable to inhibit PKD in Swiss 3T3 cells as it utilizes PKD-dependent pathway to enhance the mitogenic signaling triggered by EGF, phorbol esters and bombesin. It should, therefore, be used with caution.

Características y beneficios

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
031M4601V

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Nayden G Naydenov et al.
Tissue barriers, 1(4), e25231-e25231 (2014-03-26)
The ductal epithelium plays a key role in physiological secretion of pancreatic enzymes into the digestive system. Loss of barrier properties of the pancreatic duct may contribute to the development of pancreatitis and metastatic dissemination of pancreatic tumors. Proinflammatory cytokines
Eugenia Torres-Marquez et al.
Biochemical and biophysical research communications, 391(1), 63-68 (2009-11-10)
Recently, CID755673 was reported to act as a highly selective inhibitor of protein kinase D (PKD). In the course of experiments using CID755673, we noticed that it exerted unexpected stimulatory effects on [(3)H]thymidine incorporation and cell cycle progression in Swiss
Ali Pedram et al.
Molecular biology of the cell, 24(24), 3805-3818 (2013-10-25)
The development and progression of cardiac hypertrophy often leads to heart failure and death, and important modulators of hypertrophy include the histone deacetylase proteins (HDACs). Estrogen inhibits cardiac hypertrophy and progression in animal models and humans. We therefore investigated the
Kazuto Fujishima et al.
Development (Cambridge, England), 139(18), 3442-3455 (2012-08-23)
Neurons develop dendritic arbors in cell type-specific patterns. Using growing Purkinje cells in culture as a model, we performed a long-term time-lapse observation of dendrite branch dynamics to understand the rules that govern the characteristic space-filling dendrites. We found that
Ligia I Bastea et al.
PloS one, 7(1), e30459-e30459 (2012-01-26)
Protein kinase D1 is downregulated in its expression in invasive ductal carcinoma of the breast and in invasive breast cancer cells, but its functions in normal breast epithelial cells is largely unknown. The epithelial phenotype is maintained by cell-cell junctions
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Artículos

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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