SAB4502149

Anti-PDGF Receptor β antibody produced in rabbit

affinity isolated antibody

• Sinónimos: CD140b, PDGF-R-β, PDGFR, PDGFR-β, kinase PDGFR-β
• Número MDL: MFCD00164777
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 123 kDa
• reactividad de especies: rat, mouse, human
• concentración: ~1 mg/mL
• técnicas: ELISA: 1:40000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Nº de acceso NCBI: P09619
• Nº de acceso UniProt: P09619
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PDGFRB(5159)

Descripción

Descripción general

The PDGFRB (platelet-derived growth factor receptor β) gene is mapped to human chromosome 5q32. The encoded protein is a cell surface tyrosine kinase receptor. Anti-PDGF receptor β antibody detects endogenous levels of total PDGF receptor β protein.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human PDGF Receptor beta.

Immunogen Range: 718-767

Acciones bioquímicas o fisiológicas

PDGFRB (platelet-derived growth factor β) has its key role in cell proliferation, differentiation and survival. It also mediates cell movement and tissue repair mechanism. PDGFβ functions as a mitogen, by binding to the PDGF receptor β. Variation in PDGFRB gene leads to a number of cancer types including glioblastoma, dermatofibrosarcoma, medulloblastoma and endocrine pancreatic tumor. PDGFR-β signaling pathway, can thus serve as an important target for cancer therapy.

Características y beneficios

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Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable