SAB4301658

Anti-CSPG4 Antibody

rabbit polyclonal

• Sinónimos: HMW-MAA, MCSP, MCSPG, MSK16, NG2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• Nombre del producto: Anti-CSPG4, affinity isolated antibody
• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous glycerol solution
• reactividad de especies: human, mouse, rat
• técnicas: immunohistochemistry: 1:20-1:100; western blot: 1:500-1:2000
• nº de acceso: NP_001888
• Nº de acceso UniProt: Q6UVK1
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CSPG4(1464)

Descripción

Descripción general

Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.

Inmunógeno

Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4

Acciones bioquímicas o fisiológicas

Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.

Características y beneficios

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Forma física

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable