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Q111

Sigma-Aldrich

(±)-Quinpirole dihydrochloride

powder

Sinónimos:

trans-(±)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline dihydrochloride, LY-141,865

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About This Item

Fórmula empírica (notación de Hill):
C13H21N3 · 2HCl
Número de CAS:
73625-62-4
Peso molecular:
292.25
MDL number:
MFCD01321054
UNSPSC Code:
12352200
PubChem Substance ID:
24278670
NACRES:
NA.77

form

powder

color

white

solubility

H2O: 28 mg/mL

storage temp.

−20°C

SMILES string

Cl.Cl.[H][C@]12CCCN(CCC)[C@]1([H])Cc3cn[nH]c3C2

InChI

1S/C13H21N3.2ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;;/h9-10,13H,2-8H2,1H3,(H,14,15);2*1H/t10-,13-;;/m1../s1

InChI key

GJIGRGIGKHPYTK-OWVUFADGSA-N

Gene Information

human ... DRD2(1813)

Biochem/physiol Actions

D2-like dopamine receptor agonist that possesses some activity at D3 sites.

Legal Information

Manufactured and sold with the permission of Eli Lilly and Company.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cristina Cariulo et al.
Biochemical and biophysical research communications, 521(3), 549-554 (2019-11-05)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein can result in
D Eilam et al.
European journal of pharmacology, 161(2-3), 151-157 (1989-02-28)
The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the drug. Results showed that the
Gunnar F Kwakye et al.
Neurotoxicology, 70, 48-61 (2018-11-07)
Huntington's disease (HD) is functionally linked to environmental factors including cigarette use and dyshomeostasis in the levels of metals. Interestingly, one of the most abundant heavy metals in cigarettes is cadmium (Cd), which also accumulates in the striatum and causes
L J Munro et al.
Brain research, 746(1-2), 231-238 (1997-01-23)
Dopamine (DA) D2 and gamma-aminobutyric acid (GABA)A somatodendritic receptors tonically inhibit mesolimbic projection neurons in the A10 DA cell grouping of the ventral tegmentum. In the present study we determined the contribution of the ventral tegmental area (VTA) to the
S Rosenzweig-Lipson et al.
Pharmacology, biochemistry, and behavior, 51(4), 843-848 (1995-08-01)
The present study investigated whether potassium channel blockade could modify the behavioral effects of the dopamine D2/D3 receptor agonist quinpirole in squirrel monkeys. The duration of immobility and/or unusual postures indicative of catalepsy-associated behavior or the duration of scratching, known
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