P3134
Phosphodiesterase I from Crotalus adamanteus venom
Type VI, crude dried venom
Sinónimos:
5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
¿Está buscando productos similares? Visita Guía de comparación de productos
General description
Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs.
Application
Phosphodiesterase I from Crotalus adamanteus venom has been used:
- for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
- as a model for the hydrolysis of prodrugs in phosphodiesterase assay
- as a component in the nucleotide cleavage buffer
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. PhosphodiesteraseI (PDEI) can hydrolyze 3′,5′-cyclic adenosine monophosphate (cAMP) and3′,5′-cyclic guanosine monophosphate (cGMP). It binds to Ca2+/calmodulin(CaM) that lead to the stimulation of its catalytic activity.PDEIacts as a biotherapeutic for the treatment of cancer, heart diseases,pulmonary, metabolic, neurocognitive, renal, endocrine abnormalities, andneurological disorders.
Inhibitor
Referencia del producto
Descripción
Precios
Substrate
Referencia del producto
Descripción
Precios
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Ozone-Induced DNA Damage: A Pandora?s Box of Oxidatively Modified DNA Bases
Richard W J, et al.
Chemical Research in Toxicology (2021)
Anatoly I Dragan et al.
Nucleic acids research, 32(17), 5192-5197 (2004-10-02)
The interaction of proteins with DNA results, in some cases, in DNA bending, and this might have functional importance. However, when the protein-induced bending of DNA is small, its measurement presents a problem. It is shown that the fluorescence resonance
Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study
Roux L, et al.
European Journal of Medicinal Chemistry, 63, 869-881 (2013)
Formation of RNA oligonucleotides over the mineral surface preliminary irradiated with UV light
Otroshchenko VA and Vasilyeva NV
Reaction Kinetics and Catalysis Letters, 97(1), 151-156 (2009)
Chemical toxicity testing in vitro using cytochrome P450--expressing cell lines, such as human CYP1B1
Landsiedel R, et al.
Nature Protocols, 6(5), 677-677 (2011)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico