Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

M1694

Sigma-Aldrich

MPPG

≥97% (NMR), solid

Sinónimos:

(RS)-α-Methyl-4-phosphonophenylglycine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C9H12NO5P
Número de CAS:
169209-65-8
Peso molecular:
245.17
MDL number:
MFCD00672651
UNSPSC Code:
12352200
PubChem Substance ID:
329817701
NACRES:
NA.77

Quality Level

100

assay

≥97% (NMR)

form

solid

color

off-white

solubility

DMSO: <4 mg/mL
H2O: <4 mg/mL

SMILES string

CC(N)(C(O)=O)c1ccc(cc1)P(O)(O)=O

InChI

1S/C9H12NO5P/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H2,13,14,15)

InChI key

PAONCRJPUQXPRW-UHFFFAOYSA-N

Biochem/physiol Actions

Group III/II metabotropic glutamate (mGluR) receptor antagonist.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

T E Salt et al.
Neuropharmacology, 35(2), 239-241 (1996-02-01)
The metabotropic glutamate receptor (mGluR) agonists CCG-I and L-AP4, acting at Group II and Group III mGluRs respectively, can reduce GABAergic synaptic inhibition on single neurones in the rat thalamus in vivo via a presumed presynaptic mechanism. The actions of
T Kral et al.
Synapse (New York, N.Y.), 47(4), 278-284 (2003-01-23)
Activation of presynaptic metabotropic glutamate receptors (mGluRs) leads to a powerful inhibition of glutamate release from many synaptic terminals throughout the CNS. mGluRs as autoreceptors are believed to provide a negative feedback system that prevents potentially toxic accumulation of glutamate
Gelareh Abulwerdi et al.
Neurochemistry international, 138, 104770-104770 (2020-05-27)
Chronic dysregulated microglial activation may lead to persistent inflammation and progressive neurodegeneration. A previous study reported that ADX88178, a putative metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM), exerts anti-inflammatory effects in microglia by activating mGluR4. We employed in
Bruce A Collings
Rapid communications in mass spectrometry : RCM, 33(10), 914-924 (2019-03-12)
Quadrupole pre-filter transmission profiles are shown to be affected by the presence of trapped ions within the pre-filter of a quadrupole mass spectrometer. Trapped ions are the result of ions reflected at the pre-filter/mass filter boundary and lead to space
H N David et al.
Neuropharmacology, 44(6), 717-727 (2003-04-12)
Previous investigations have shown that mGlu receptors would be involved in the amphetamine-induced motor response. However, data are somewhat controversial across studies where methodological protocols vary. The aim of the present study was to determine the involvement of mGlu receptors

Artículos

Glutamate Receptors (G Protein Family)

Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.

Glutamate Receptors (G Protein Family)

Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.

Glutamate Receptors (G Protein Family)

Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.

Glutamate Receptors (G Protein Family)

Sigma-Aldrich offers many products related to G-protein family glutamate receptors for your research needs.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico