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L6004

Sigma-Aldrich

Lincomycin hydrochloride

≥90% (TLC)

Sinónimos:

Epilincomycin, Lincomycin HCL, Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C18H34N2O6S · HCl
Número de CAS:
859-18-7
Peso molecular:
443.00
Beilstein:
4171650
Número CE:
212-726-7
Número MDL:
MFCD00083647
Código UNSPSC:
51284507
ID de la sustancia en PubChem:
329817633
NACRES:
NA.85

Nivel de calidad

200

Ensayo

≥90% (TLC)

potencia

800-900 units per mg

color

white to faint yellow

solubilidad

H2O: soluble 50 mg/mL

espectro de actividad antibiótica

Gram-positive bacteria

Modo de acción

protein synthesis | interferes

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

Clave InChI

POUMFISTNHIPTI-BOMBIWCESA-N

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Descripción general

Chemical structure: macrolide

Aplicación

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance, and protein and surfactant binding It is produced by Streptomyces lincolnensis var. lincolnensis.

Acciones bioquímicas o fisiológicas

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Nota de preparación

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H315,H319,H335

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
112K0566
WXBF4028V
WXBF1860V
WXBF0162V
WXBD7899V

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Neelam Keswani et al.
Journal of biochemistry, 148(1), 71-84 (2010-04-02)
The thermodynamics of interaction of neomycin and lincomycin with bovine serum albumin (BSA) and human serum albumin (HSA) has been studied using isothermal titration calorimetry (ITC), in combination with UV-visible, steady state and time resolved fluorescence spectroscopic measurements. Neomycin is
Charlotte M M Gommers et al.
Plant physiology, 185(1), 67-76 (2021-02-26)
When germinating in the light, Arabidopsis (Arabidopsis thaliana) seedlings undergo photomorphogenic development, characterized by short hypocotyls, greening, and expanded cotyledons. Stressed chloroplasts emit retrograde signals to the nucleus that induce developmental responses and repress photomorphogenesis. The nuclear targets of these
H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
Kazunori Miyata et al.
Photosynthesis research, 113(1-3), 165-180 (2012-07-17)
When visible light is excess, the photosynthetic machinery is photoinhibited. The extent of net photoinhibition of photosystem II (PSII) is determined by a balance between the rate of photodamage to D1 and some other PSII proteins and the rate of
Carmen Lozano et al.
International journal of antimicrobial agents, 40(4), 306-312 (2012-08-21)
Nine staphylococcal strains of human and animal origin with a lincomycin-resistant/erythromycin-susceptible phenotype and carrying vga genes were characterised to determine the genetic elements involved in the dissemination of these uncommon resistance genes. These strains were typed by multilocus sequence typing
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