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C2250000

Clindamicina hydrochloride

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

(7S) -7-Cloro-7-desoxilincomicina hydrochloride, Cleocina

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About This Item

Fórmula empírica (notación de Hill):
C18H33ClN2O5S · HCl
Número de CAS:
21462-39-5
Peso molecular:
461.44
Beilstein/REAXYS Number:
4070786
MDL number:
MFCD07793327
UNSPSC Code:
41116107
PubChem Substance ID:
329774985
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

clindamycin

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1

InChI key

AUODDLQVRAJAJM-XJQDNNTCSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clindamycin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

La clindamicina es un antibiótico lincosamida semisintético que se prepara a partir de la lincomicina. Inhibe la síntesis de proteínas bacterianas mediante interacciones de enlaces de hidrógeno con el componente 23S del ARNr de la subunidad ribosómica 50S induciendo así la disociación del complejo peptidil-t-ARN. Tiene actividad anti bacteriana contra los cocos grampositivos y actividad antiprotozoaria contra Toxoplasma.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Antibiótico antibacteriano y antiprotozoario de la clase lincosamida.
Sales restrictions may apply.

related product

Referencia del producto
Descripción
Precios

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Lact. - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

Lo sentimos, en este momento no disponemos de COAs para este producto en línea.

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Antimicrobial agents and chemotherapy, 57(3), 1538-1541 (2013-01-09)
A total of 146 group B streptococcus isolates from 8 cities across China belonged to four serotypes. Serotype Ia was more common in children. A high prevalence of resistance was observed for levofloxacin (37.7%), erythromycin (71.2%), clindamycin, (53.4%), and tetracycline
John W Barlow et al.
BMC veterinary research, 9, 28-28 (2013-02-13)
Treatment of subclinical mastitis during lactation can have both direct (individual animal level) and indirect (population level) effects. With a few exceptions, prior research has focused on evaluating the direct effects of mastitis treatment, and to date no controlled field
Orli Megged et al.
The Israel Medical Association journal : IMAJ, 15(1), 27-30 (2013-03-15)
Resistance to macrolides in beta-hemolytic streptococci and Streptococcus pneumoniae arises primarily due to Erm(B) or Mef(A). Erm(B) typically confers high level resistance to macrolides, lincosamides and streptogramin B (MLSB phenotype), whereas Mef(A) confers low level resistance to macrolides only (M
D Gonzalez et al.
Clinical pharmacology and therapeutics, 96(4), 429-437 (2014-06-21)
Clindamycin is commonly prescribed to treat children with skin and skin-structure infections (including those caused by community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)), yet little is known about its pharmacokinetics (PK) across pediatric age groups. A population PK analysis was performed in
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