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G5779

Sigma-Aldrich

Gly-Pro-Arg-Pro amide

≥97% (HPLC)

Sinónimos:

GPRP amide, Glycine-Proline-Arginine-Proline amide, Glycyl-L-prolyl-L-arginyl-L-prolinamide

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About This Item

Fórmula empírica (notación de Hill):
C18H32N8O4
Número de CAS:
126047-75-4
Peso molecular:
424.50
Número MDL:
MFCD00237962
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24895231
NACRES:
NA.32

Nivel de calidad

200

Ensayo

≥97% (HPLC)

Nº de acceso UniProt

P02751
P04937
P11276

temp. de almacenamiento

−20°C

cadena SMILES

NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(N)=O

InChI

1S/C18H32N8O4/c19-10-14(27)25-8-3-6-13(25)16(29)24-11(4-1-7-23-18(21)22)17(30)26-9-2-5-12(26)15(20)28/h11-13H,1-10,19H2,(H2,20,28)(H,24,29)(H4,21,22,23)/t11-,12-,13-/m0/s1

Clave InChI

SCCTZYGEMPQRCV-AVGNSLFASA-N

Información sobre el gen

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Amino Acid Sequence

Gly-Pro-Arg-Pro-NH2

Descripción general

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.

Aplicación

Gly-Pro-Arg-Pro amide has been used-
  • as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin
  • for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice
  • during preparation of human soluble fibrin, to block the polymerization of soluble fibrin

Acciones bioquímicas o fisiológicas

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCH9460
BCCK7862
BCCF7522
BCCC2077
BCBZ2877

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P C Liaw et al.
The Journal of biological chemistry, 276(24), 20959-20965 (2001-04-11)
Although fibrin-bound thrombin is resistant to inactivation by heparin.antithrombin and heparin.heparin cofactor II complexes, indirect studies in plasma systems suggest that the dermatan sulfate.heparin cofactor II complex can inhibit fibrin-bound thrombin. Herein we demonstrate that fibrin monomer produces a 240-fold
P Klement et al.
Journal of thrombosis and haemostasis : JTH, 1(3), 587-594 (2003-07-23)
Although hirudin is better than heparin at preventing recurrent ischemia in patients with unstable angina, hirudin produces more bleeding. The purpose of this study was to use a rabbit arterial thrombosis prevention and ear bleeding model to determine whether for
Leonardo Pasalic et al.
Methods in molecular biology (Clifton, N.J.), 1646, 369-389 (2017-08-15)
Flow cytometry is a powerful tool for rapid evaluation of multiple functional properties of large numbers of platelets in whole blood. In the following chapter, we provide a number of flow cytometry-based protocols broadly aimed at (1) assessment of constitutively
Christine S M Lee et al.
Methods in molecular biology (Clifton, N.J.), 2663, 441-461 (2023-05-19)
Heparin-induced thrombocytopenia (HIT) is a well-characterized, iatrogenic complication of heparin anticoagulation with significant morbidity. In contrast, vaccine-induced immune thrombotic thrombocytopenia (VITT) is a recently recognized severe prothrombotic complication of adenoviral vaccines, including the ChAdOx1 nCoV-19 (Vaxzevria, AstraZeneca) and Ad26.COV2.S (Janssen
Chuen Wen Tan et al.
Methods in molecular biology (Clifton, N.J.), 1967, 305-321 (2019-05-10)
Flow cytometry assessment of platelets using the combination of GSAO [4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid], a dithiol-reactive probe, and P-selectin, a platelet activation marker, is a novel and powerful assay in the identification and quantification of the procoagulant subpopulation of platelets that has
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