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Key Documents

G3046

Sigma-Aldrich

GDF-15 human

Sinónimos:

Growth Differentiation Factor 15 human, MIC-1, Macrophage inhibitory cyotkine-1

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About This Item

Número de CAS:
1821355-80-9
UNSPSC Code:
12352202
NACRES:
NA.26

biological source

human

Quality Level

100

recombinant

expressed in CHO cells

assay

>97% (visualized with silver stain, SDS-PAGE)

form

lyophilized powder

mol wt

dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

Q99988

storage temp.

−20°C

Gene Information

human ... GDF15(9518)

General description

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.2 It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.

Application

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

Biochem/physiol Actions

Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.

Analysis Note

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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K P Bland et al.
Quarterly journal of experimental physiology (Cambridge, England), 74(6), 813-824 (1989-11-01)
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P E Rose et al.
British medical journal (Clinical research ed.), 294(6569), 411-412 (1987-02-14)
Jennifer Lee et al.
PloS one, 10(6), e0131506-e0131506 (2015-06-27)
Although inactivating frameshift mutations in the Transforming growth factor beta receptor type 2 (TGFBR2) gene are considered as drivers of microsatellite unstable (MSI) colorectal tumorigenesis, consequential alterations of the downstream target proteome are not resolved completely. Applying a click-it chemistry

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