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B9688

Sigma-Aldrich

Pizotifen

≥98% (HPLC)

Sinónimos:

Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine

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About This Item

Fórmula empírica (notación de Hill):
C19H21NS
Número de CAS:
15574-96-6
Peso molecular:
295.44
EC Number:
239-632-9
MDL number:
MFCD00864192
UNSPSC Code:
12352200
PubChem Substance ID:
329773323
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥8 mg/mL

originator

Novartis

storage temp.

room temp

SMILES string

CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24

InChI

1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

InChI key

FIADGNVRKBPQEU-UHFFFAOYSA-N

Biochem/physiol Actions

Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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C E Serna-Jiménez et al.
Biomedical chromatography : BMC, 26(6), 769-774 (2011-10-18)
Pizotifen malate is an antihistamine and serotonin inhibitor used in the preventive treatment of migraine and eating disorders. A simple, rapid, accurate and precise high-performance liquid chromatography (HPLC) method involving ultraviolet detection was validated for the quantitative analysis of pizotifen
Richard Young et al.
Pharmacology, biochemistry, and behavior, 82(2), 404-410 (2005-10-29)
MDMA (N-methyl-3,4-methylenedioxyamphetamine) produces a discriminative stimulus (DS) effect in animals, but attempts to completely block this action with selective neurotransmitter antagonists have not been very successful. Biochemically, MDMA can increase synaptic levels of serotonin, dopamine, and norepinephrine that, conceivably, might
Abdeslam Chagraoui et al.
Psychopharmacology, 170(1), 17-22 (2003-08-09)
Agomelatine, an antidepressant with melatonin agonist and 5-HT(2C) antagonist properties, as well as two of its main metabolites, S 21517 (N-[2-(7-hydroxy-1-naphtyl)ethyl]acetamide) and S21540 (N-[2-(3-hydroxy-7-methoxynaphtalen-1-yl)ethyl]acetamide), have been assessed in vitro on pig choroid plexus preparations to determine their affinities for 5-HT(2C)
M H Guillet et al.
Annales de dermatologie et de venereologie, 122(11-12), 777-779 (1995-01-01)
Primary erythermalgia is a rare acrosyndrome due to paroxystic arteriolar dilatation of extremities that become red and congested with warmth and burning sensation or pain. We report herein the observation of a primary erythermalgia affecting 3 degrees in the same
Arthur T Strachan et al.
Medicine and science in sports and exercise, 37(3), 389-394 (2005-03-03)
The effect of serotonin (5-HT)2C receptor blockade on the thermal response and exercise performance during exercise in a warm environment was examined. Seven endurance-trained, but not heat-acclimatized, individuals (six males and one female) performed two 40-km time trials on a
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