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Key Documents

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B0186

Sigma-Aldrich

BI-6C9

≥97% (HPLC), solid

Sinónimos:

N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

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About This Item

Fórmula empírica (notación de Hill):
C23H25N3O4S2
Número de CAS:
791835-21-7
Peso molecular:
471.59
MDL number:
MFCD07784498
UNSPSC Code:
12352200
PubChem Substance ID:
24724408
NACRES:
NA.77

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

off-white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc2ccc(Sc3ccc(N)cc3)cc2

InChI

1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)

InChI key

LCFUJBSKPDPGKO-UHFFFAOYSA-N

Biochem/physiol Actions

BI-6C9 is a tBid inhibitor and antiapoptotic.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Paolo Armando Gagliardi et al.
The Journal of cell biology, 217(1), 231-249 (2017-11-23)
Extrusion of apoptotic cells from epithelial tissues requires orchestrated morphological rearrangements of the apoptotic cell and its neighbors. However, the connections between the apoptotic cascade and events leading to extrusion are not fully understood. Here, we characterize an apoptotic extrusion
Xinwen Liao et al.
Journal of Cancer, 10(16), 3678-3690 (2019-07-25)
Chaetocin, a natural product extracted from Chaetomium species, possesses anticancer effects in several kinds of tumors. However, it remains unclear whether the potential indication for chaetocin could also include human gastric cancer. We found here that chaetocin induced caspase-dependent and
Lihua Hu et al.
Neurotoxicology, 49, 149-157 (2015-06-27)
Although there are few studies suggested PCP exposure induced developmental and behavioral disorders, however, the occurrence of neurotoxicity and PCP has not been firmly established. Tetrachlorobenzoquinone (TCBQ) is a reactive metabolite of environmental pollutant pentachlorophenol (PCP). To the best of
Sina Oppermann et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 273-289 (2014-05-23)
Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed
Marieta B Heaton et al.
Alcoholism, clinical and experimental research, 39(1), 55-63 (2015-01-28)
Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcohol spectrum disorder classification. One mode of EtOH-induced interference in the normal developmental
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