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Merck
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Documentos clave

445R-1

Sigma-Aldrich

NKX2.2 (EP336) Rabbit Monoclonal Primary Antibody

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About This Item

Código UNSPSC:
12352203

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP336, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (445R-14)
vial of 0.1 mL concentrate Research Use Only (445R-14-RUO)
vial of 0.5 mL concentrate (445R-15)
vial of 1.0 mL concentrate (445R-16)
vial of 1.0 mL concentrate Research Use Only (445R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (445R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (445R-17)
vial of 7.0 mL pre-dilute ready-to-use (445R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (445R-18-RUO)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotipo

IgG

control

Ewing’s sarcoma, pancreas

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

nuclear

Descripción general

NKX2.2 is a homeodomain transcription factor that plays a role in neuroendocrine and glial differentiation. NKX2.2 is upregulated in Ewing′s sarcoma as a result of the oncogenic EWS-FLI1 fusion protein. As one of many small round blue cell tumors, Ewing′s sarcoma can be difficult to diagnose due to the characteristic undifferentiated morphology. NKX2.2 has proven its utility as a sensitive maker for distinguishing Ewing′s sarcoma from other round blue cell tumors when used in a panel.

Calidad


IVD

IVD

IVD

RUO

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Arvind Rajwanshi et al.
Journal of cytology, 26(1), 1-10 (2009-01-01)
Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells. They generally include Ewing's sarcoma, peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms' tumor. Other differential diagnoses of small round
Yoshinari Yamamoto et al.
Journal of cytology, 32(1), 30-32 (2015-05-08)
Renal Ewing sarcoma (ES) is a rare malignant tumor characterized by fusion of the EWSR1 gene with a member of the ETS family of oncogenes, arising at a specific chromosomal translocation. Diagnosis of ES can be problematic, especially from cytological
Richard Smith et al.
Cancer cell, 9(5), 405-416 (2006-05-16)
Our understanding of Ewing's sarcoma development mediated by the EWS/FLI fusion protein has been limited by a lack of knowledge regarding the tumor cell of origin. To circumvent this, we analyzed the function of EWS/FLI in Ewing's sarcoma itself. By
Yin P Hung et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29(4), 370-380 (2016-02-06)
Ewing sarcoma shows considerable histologic overlap with other round cell tumors. NKX2-2, a homeodomain transcription factor involved in neuroendocrine/glial differentiation and a downstream target of EWSR1-FLI1, has been reported as an immunohistochemical marker for Ewing sarcoma. We assessed the specificity
Akihiko Yoshida et al.
The American journal of surgical pathology, 36(7), 993-999 (2012-03-27)
Ewing sarcoma is a high-grade round cell sarcoma that affects bones and soft tissues in children and young adults. Its diagnosis can be challenging, and the differential diagnoses include a wide variety of small round cell tumors. CD99 and FLI-1

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