The S100 protein 330M-18 consists of both alpha and beta subunits. This protein belongs to the family of calcium-binding proteins, similar to calmodulin and troponin C. Specifically, S100A is composed of an alpha and beta chain, while S100B is composed of two beta chains. Furthermore, the S100 protein is expressed in antigen-presenting cells, including Langerhans cells in the skin and interdigitating reticulum cells in the paracortex of lymph nodes.
330M-1
S-100 (4C4.9) Mouse Monoclonal Antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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Productos recomendados
biological source
mouse
Quality Level
100
500
conjugate
unconjugated
antibody form
diluted ascites fluid
antibody product type
primary antibodies
clone
4C4.9, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (330M-14)
vial of 0.5 mL concentrate (330M-15)
bottle of 1.0 mL predilute (330M-17)
vial of 1.0 mL concentrate (330M-16)
bottle of 7.0 mL predilute (330M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
isotype
IgG2a
control
melanoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic, nuclear
Gene Information
human ... S100A1(6271)
General description
S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.[1][2][3]Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly.[1][2][4][5] A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue,[4] and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.[5][6] Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.[1][2][4][5][6][3]
Quality
 IVD |  IVD |  IVD |  RUO |
Linkage
S-100 Positive Control Slides, Product No. 330S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
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Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
L Monda et al.
Human pathology, 16(3), 287-293 (1985-03-01)
In an effort to investigate the utility of immunostaining for S-100 protein in the differential diagnosis of chondroblastoma, the expression of S-100 protein in nine chondroblastomas was compared with that in six giant cell tumors, six aneurysmal bone cysts, four
Purvisha Patel et al.
Journal of the American Academy of Dermatology, 46(2), 264-270 (2002-01-25)
Malignant myxoid melanoma (MMM) is a rarely reported variant of malignant melanoma, which can often be confused with other mucin-containing neoplasms. A retrospective study of 3 cases of MMM and a review of the English-language literature was performed. MMM affects
The immunohistochemical localization of S100 in the diagnosis of papillary carcinoma of the thyroid.
K M McLaren et al.
Human pathology, 27(7), 633-636 (1996-07-01)
In general, the diagnosis of papillary carcinoma of the thyroid is readily achieved based on a defined aggregate of histopathologic features. A papillary architecture is an important but not pivotal component of the diagnosis. The recognition of classic nuclear features
T Nakajima et al.
The American journal of surgical pathology, 6(8), 715-727 (1982-12-01)
The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases). Peripheral nerve tumors, i.e., schwannomas, neurofibromas, granular cell tumors, and neurogenic sarcomas were demonstrated to contain variable amounts of S-100 protein in
H J Kahn et al.
American journal of clinical pathology, 79(3), 341-347 (1983-03-01)
Normal tissues and various tumors were examined for S100 protein, using anti-S100 protein antiserum, in an immunoperoxidase reaction. Among normal tissues, in addition to the previously reported presence of S100 protein in some neurons, glial, and Schwann cells of the
Artículos
IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.
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