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PHR1584

Supelco

Donepezil Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Donepezil hydrochloride, (±)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride, 2,3-Dihydro-5,6-dimethoxy-2-{[1-(phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one

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About This Item

Fórmula empírica (notación de Hill):
C24H29NO3 · HCl
Número de CAS:
Peso molecular:
415.95
Código UNSPSC:
41116107
NACRES:
NA.24
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grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to USP 1224981

familia API

donepezil

CofA

current certificate can be downloaded

envase

pkg of 1 g

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

[Cl-].N2(CCC(CC2)CC3Cc4c(cc(c(c4)OC)OC)C3=O)Cc1ccccc1.[H+]

InChI

1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

Clave InChI

XWAIAVWHZJNZQQ-UHFFFAOYSA-N

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Donepezil Hydrochloride is known as a selective, reversible inhibitor of acetylcholinesterase enzyme. It exhibits therapeutic effect by raising the acetylcholine concentrations and improving the cholinergic function. It can be used in the treatment of mild to moderate dementia of the Alzheimer′s type.[1][2]

Aplicación

Donepezil Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[1][3] and plasma samples[2][3] by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB3756 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Skull and crossbones

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 2 Oral - Eye Irrit. 2

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Quantitative determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry employing an automated liquid?liquid extraction based on 96-well format plates: Application to a bioequivalence study.
Apostolou C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 848(2), 239-244 (2007)
Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats.
Radwan MA, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 830(1), 114-119 (2006)
A new HPLC method to determine Donepezil hydrochloride in tablets.
Pappa H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 27(1-2), 177-182 (2002)

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