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Merck

B5775

Supelco

Bendroflumethiazide

analytical standard

Sinónimos:

3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Fórmula empírica (notación de Hill):
C15H14F3N3O4S2
Número de CAS:
Peso molecular:
421.41
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F

InChI

1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)

InChI key

HDWIHXWEUNVBIY-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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General description

Bendroflumethiazide belongs to the class of thiazide diuretics, widely used in enhancing diuresis. It is also used as an effective antihypertensive agent and in the treatment of edema caused by cardiac/renal failure and myocardial infarction. Its mode of action involves increasing the urine flow and the net renal excretion of both sodium and water.

Application

Bendroflumethiazide may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

David S Wald et al.
Journal of evaluation in clinical practice, 18(3), 612-615 (2011-02-01)
A combination of medications that simultaneously reduce several cardiovascular risk factors in people above a specified age, without selection based on risk factor measurement, has been proposed as a simple strategy for reducing the risk of cardiovascular disease and shown
Hari K Parthasarathy et al.
Journal of hypertension, 28(1), 170-177 (2009-12-17)
We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750
Quaisar Ali et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 35(6), 654-660 (2012-02-03)
Previously, we demonstrated that angiotensin II type 2 (AT(2)) receptors have a role in natriuresis in obese Zucker rats (OZR). In the present study, we investigated the role of a novel, non-peptide agonist, C21, in natriuresis via AT(2) receptor activation
Neil R Poulter et al.
Journal of the American College of Cardiology, 54(13), 1154-1161 (2009-09-19)
The aim of this study was to evaluate the effect of baseline heart rate on the efficacy of atenolol-based compared with amlodipine-based therapy in patients with hypertension uncomplicated by coronary heart disease in the ASCOT-BPLA (Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure
Analysis of diuretic doping agents by HPLC screening and GC?MSD confirmation
Tsai Y-F, et al.
Journal of Pharmaceutical and Biomedical Analysis, 9(10-12), 1069-1076 (1991)

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