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Merck

38907

Supelco

Isorhamnetin

analytical standard

Sinónimos:

3′-Methoxy-3,4′,5,7-tetrahydroxyflavone, 3′-Methylquercetin, 3,4′,5,7-Tetrahydroxy 3′-methoxyflavone, Isorhamnetol, Quercetin 3′-methyl ether

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About This Item

Fórmula empírica (notación de Hill):
C16H12O7
Número de CAS:
Peso molecular:
316.26
Beilstein/REAXYS Number:
44723
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3

InChI key

IZQSVPBOUDKVDZ-UHFFFAOYSA-N

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General description

Isorhamnetin belongs to the flavonoids class of compounds.

Application

Isorhamnetin may be used as an analytical reference standard for the determination of isorhamnetin in:
  • Rat plasma samples by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) equipped with electrospray ionization (ESI) and multiple reaction monitoring (MRM) mode of detection.
  • Lotus (Nelumbo nucifera) leaves by macroporous resin chromatography combined with HPLC-ESI-MS/MS.
  • Powdered extracts and finished products samples of Ginkgo biloba by HPLC-MS.
  • Human plasma and urine by high-throughput micro solid-phase extraction (μ-SPE), followed by analysis using UHPLC in interface with quadrupole time-of-flight mass spectrometry (Q TOFMS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: ginkgo glycyrrhiza primula

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Analysis of flavonoids in lotus (Nelumbo nucifera) leaves and their antioxidant activity using macroporous resin chromatography coupled with LC-MS/MS and antioxidant biochemical assays.
Zhu MZ, et al.
Molecules (Basel), 20(6), 10553-10565 (2015)
Elise F Hoek-van den Hil et al.
Analytical and bioanalytical chemistry, 402(3), 1389-1392 (2011-11-29)
Flavonoids are bioactive food compounds with potential lipid-lowering effects. Commercially available enzymatic assays are widely used to determine free fatty acid (FFA) and triglyceride (TG) levels both in vivo in plasma or serum and in vitro in cell culture medium
Sarah Egert et al.
The British journal of nutrition, 107(4), 539-546 (2011-07-22)
The flavonol quercetin, is one of the major flavonoids found in edible plants. The bioavailability of quercetin in humans may be influenced by the food matrix in which it is consumed as well as by its chemical and physical form.
Development and validation of a high-throughput micro solid-phase extraction method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid identification and quantification of phenolic metabolites in human plasma and urine.
Feliciano RP, et al.
Journal of Chromatography A, 1464(4), 21-31 (2016)

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