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Merck
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Key Documents

2106

Sigma-Aldrich

Heparina sodium salt from porcine intestinal mucosa

endotoxin, free

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About This Item

Número de CAS:
9041-08-1
MDL number:
MFCD00081689
UNSPSC Code:
12352201
NACRES:
NA.21

biological source

Porcine intestinal mucosa

Quality Level

200

form

powder

usage

sufficient for 5 mL blood anticoagulant

packaging

preweighed vial of 300 USP units

impurities

endotoxin, free

color

beige

solubility

water: soluble 50 g/L
acetone: insoluble
alcohol: insoluble
benzene: insoluble
chloroform: insoluble
diethyl ether: insoluble

compatibility

for use with E-Toxate™

storage temp.

room temp

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Application

Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells.

Biochem/physiol Actions

Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer.

Caution

Not for injection.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Legal Information

E-Toxate is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000403947
0000403947
0000260909
SLCQ6590
SLCK0042

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Mechanism of the anticoagulant action of heparin.
I Björk et al.
Molecular and cellular biochemistry, 48(3), 161-182 (1982-10-29)
Overexpression of Functional SLC6A3 in Clear Cell Renal Cell Carcinoma.
Jennifer Hansson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(8), 2105-2115 (2016-09-25)
Nada M S Al-Saffar et al.
British journal of cancer, 119(9), 1118-1128 (2018-11-01)
AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT signalling would result in metabolic changes that could potentially be
L B Schwartz et al.
The Journal of biological chemistry, 261(16), 7372-7379 (1986-06-05)
Tryptase was shown to be stabilized as an enzymatically active tetramer by association with heparin and dissociated to inactive monomers in the absence of heparin at 37 degrees C in physiologic buffer and in plasma. There was a 50% loss
Circulation, 55(2), 423-426A-423-426A (1977-02-01)
Presently available data indicate that low-dose heparin will significantly diminish postoperative deep venous thrombosis and pulmonary embolism in patients over the age of 40 subjected to major elective abdomino-thoracic surgery. The schedule is 5,000 USP units of heparin subcutaneously beginning
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