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OP44

Sigma-Aldrich

Anti-APC (Ab-1) Mouse mAb (FE9)

liquid, clone FE9, Calbiochem®

Sinónimos:

Anti-Adenomatous Polyposis Coli

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.43

origen biológico

mouse

Nivel de calidad

forma del anticuerpo

purified antibody

tipo de anticuerpo

primary antibodies

clon

FE9, monoclonal

Formulario

liquid

contiene

≤0.1% sodium azide as preservative

reactividad de especies

rat, human, mouse

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

do not freeze

isotipo

IgG1

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... APC(324)

Descripción general

Anti-APC (Ab-1), mouse monoclonal, clone FE9, recognizes full length APC (p300) in HCT116 cells and truncated APC (p147) in SW480 cells. It is validated for Western botting.
Protein G purified mouse monoclonal antibody generated by immunizing mice with the specified immunogen and fusing splenocytes with SP40 cells. Recognizes the ~300 kDa APC protein as well as a variety of truncated forms.
Recognizes full length APC (p300) in HCT116 cells and truncated APC (p147) in SW480 cells.
  • Antibody Target Gene Symbol: APC
  • Target Synonym: AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC
  • Entrez Gene Name: adenomatous polyposis coli
  • Hu Entrez ID: 324 (Related Antibodies: OP80, ST1150, OP62, OP47L)
  • Mu Entrez ID: 11789
  • Rat Entrez ID: 24205
  • Inmunógeno

    a synthetic peptide corresponding to the N-terminal 35 amino acids of APC

    Aplicación

    Immunoblotting (1 µg/ml, see comments)

    Envase

    Please refer to vial label for lot-specific concentration.

    Advertencia

    Toxicity: Standard Handling (A)

    Forma física

    In 50 mM sodium phosphate buffer, pH 7.5, 0.2% gelatin.

    Nota de análisis

    Positive Control
    HCT116 cells for p300, SW480 cells for truncated APC (p147)

    Otras notas

    Koetsier, P. A., et al. 1993. BioTechniques15, 258.
    Smith, K. J., et al. 1993. Proc. Natl. Acad. Sci., USA90, 2846.
    Su, L.-K., et al. 1993. Can. Res.53, 2728.
    Boynton, R. F., et al. 1992. Proc. Natl. Acad. Sci. USA89, 3385.
    D′Amico, D., et al. 1992. Cancer Res.52, 1996.
    Fearon, E. R., and Jones, P. A., 1992. FASEB J.6, 2783.
    Miyoshi, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 4452.
    Powell, S. M., et al. 1992. Nature359, 235.
    Groden, J., et al. 1991. Cell66, 589.
    Kinzler, K. W., et al. 1991. Science253, 661.
    Nishisho, I., et al. 1991. Science253, 665.

    Información legal

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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    Código de clase de almacenamiento

    11 - Combustible Solids

    Clase de riesgo para el agua (WGK)

    WGK 1

    Punto de inflamabilidad (°F)

    Not applicable

    Punto de inflamabilidad (°C)

    Not applicable


    Certificados de análisis (COA)

    Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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    Hideaki Toki et al.
    Cancer science, 104(7), 937-944 (2013-04-05)
    Mutant mouse models are indispensable tools for clarifying the functions of genes and elucidating the underlying pathogenic mechanisms of human diseases. We carried out large-scale mutagenesis using the chemical mutagen N-ethyl-N-nitrosourea. One specific aim of our mutagenesis project was to
    Mireia Menéndez et al.
    Gastroenterology, 134(1), 56-64 (2008-01-02)
    We identified the APC N1026S variant of unknown malignant potential in the adenomatous polyposis coli (APC) gene in a Spanish attenuated familial adenomatous polyposis (AFAP) family. The variant was located in the first of the 4 highly conserved 15-amino acid
    Tamar Evron et al.
    Oncogenesis, 10(9), 63-63 (2021-09-24)
    The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the development and progression of colorectal
    Nathaniel S Rial et al.
    International journal of cancer, 124(10), 2270-2280 (2009-01-29)
    Elevated deoxycholic acid (DCA), mutations in the adenomatous polyposis coli (APC) gene and chronic inflammation are associated with increased risk of colorectal cancer. APC status was manipulated to determine whether DCA mediates inflammatory molecules in normal or initiated colonic mucosa.
    Claudia Gaspar et al.
    PLoS genetics, 5(7), e1000547-e1000547 (2009-07-07)
    Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra-intestinal tumors. Moreover, somatic APC mutations

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