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Key Documents

CBL243

Sigma-Aldrich

Anti-Glucose Transporter GLUT-4 Antibody

Chemicon®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC2A4(6517)

Specificity

Specific for human glucose transporter-4 from muscle and adipose tissue. The antisera does not cross-react with GLUT-1. The molecular weight of the glucose transporter precipitated by the serum is approximately 46 kDa.

Immunogen

Partially purified GLUT-4

Application

Research Category
Signaling
Research Sub Category
Insulin/Energy Signaling
This Anti-Glucose Transporter GLUT-4 Antibody is validated for use in IP, WB for the detection of Glucose Transporter GLUT-4.
Western blot analysis of GLUT-4 activity in adipose and muscle tissue (5μg/ml)

Immunoprecipitation of GLUT-4 (5μg/ml)

Optimal working dilutions must be determined by the end user.

Target description

46 kDa

Physical form

ImmunoAffinity Purified
Purified immunoglobulin in PBS with 0.01% sodium azide.

Storage and Stability

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.

Analysis Note

Control
Positive Control: 3T3 L1 adipocyte membranes

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Referencia del producto
Descripción
Precios

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Haiyan Wang et al.
Facets (Ottawa), 7, 774-791 (2022-11-17)
Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes reported that treatment with
Haiyan Wang et al.
Journal of applied physiology (Bethesda, Md. : 1985), 132(1), 140-153 (2021-12-10)
Previous studies demonstrated that acute exercise can enhance glucose uptake (GU), γ3-AMP-activated protein kinase (AMPK) activity, and Akt substrate of 160 kDa (AS160) phosphorylation in skeletal muscles from low-fat diet (LFD)- and high-fat diet (HFD)-fed male rats. Because little is
Xiaohua Zheng et al.
PloS one, 15(2), e0223340-e0223340 (2020-02-14)
The Rab GTPase activating protein known as Akt substrate of 160 kDa (AS160 or TBC1D4) regulates insulin-stimulated glucose uptake in skeletal muscle, the heart, and white adipose tissue (WAT). A novel rat AS160-knockout (AS160-KO) was created with CRISPR/Cas9 technology. Because
Naveen Sharma et al.
Biochimica et biophysica acta, 1822(11), 1735-1740 (2012-08-01)
Calorie restriction (CR; ~60% of ad libitum, AL, consumption) improves insulin-stimulated glucose uptake in skeletal muscle. The precise cellular mechanism for this healthful outcome is unknown, but it is accompanied by enhanced insulin-stimulated activation of Akt. Previous research using Akt2-null
Roberto A Gulli et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 303(10), R1062-R1070 (2012-10-12)
High-fat (HF) diets impair skeletal muscle response to the insulin-sensitizing adipokine adiponectin (Ad) in rodents, preceding the development of insulin resistance. Skeletal muscle insulin response in HF-fed rats can be restored with chronic exercise; whether recovery of skeletal muscle Ad

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