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420139

Sigma-Aldrich

JAK2 Inhibitor IV

The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sinónimos:

JAK2 Inhibitor IV, 3-Amino-5-(N- tert-butylsulfonamido-4-phenyl)-indazole

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About This Item

Fórmula empírica (notación de Hill):
C17H20N4O2S
Número de CAS:
1110502-30-1
Peso molecular:
344.43
MDL number:
MFCD16495796
UNSPSC Code:
12352200
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

ethanol: 3 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC(C)(C)C)c1ccc(cc1)c2cc3c([nH]nc3N)cc2

InChI

1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20)

InChI key

KFJCXIOVAGJCKB-UHFFFAOYSA-N

General description

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yong Yu et al.
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Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization. P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) is a type of small non-coding RNA implicated in a variety
Md Al Nayem Chowdhury et al.
Cell death & disease, 13(7), 619-619 (2022-07-20)
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase

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