360512

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

• Sinónimos: Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
• Número de CAS: 863-57-0
• Número MDL: MFCD00669624
• Código UNSPSC: 12352106
• NACRES: NA.21

Propiedades

• Nivel de calidad: 100
• descripción: Merck USA index - 14, 4494
• Ensayo: 100.1% dry basis (titration)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• número de agregación: 2.1
• color: white to off-white
• pKa: 3.8
• CMC: 7.1 mM
• solubilidad: water: 200 mg/mL; ethanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 15-25°C
• cadena SMILES: [Na+].N(CC(=O)[O-])C(=O)CCC(C1C2(C(C3C(C4(C(CC3O)CC(CC4)O)C)CC2O)CC1)C)C
• InChI: 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
• Clave InChI: OABYVIYXWMZFFJ-UHFFFAOYSA-M

Descripción

Descripción general

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pK_a: 3.8).

Aplicación

Glycocholic Acid, Sodium Salt- is suitable for use:

• as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
• in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
• to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K₁) to analyze its influence on the quality and stability of the mixed micelle systems

Acciones bioquímicas o fisiológicas

Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).

Advertencia

Toxicity: Standard Handling (A)

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable