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N-075

Supelco

(±)-N′-Nitrosonornicotine (NNN) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

NNN, NNN solution

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About This Item

Fórmula empírica (notación de Hill):
C9H11N3O
Número de CAS:
80508-23-2
Peso molecular:
177.20
Código UNSPSC:
41116107
NACRES:
NA.24

grado

certified reference material

Nivel de calidad

300

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

1.0 mg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

forensics and toxicology

Formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

O=NN1CCCC1c2cccnc2

InChI

1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2

Clave InChI

XKABJYQDMJTNGQ-UHFFFAOYSA-N

Categorías relacionadas

Descripción general

N′-Nitrosonornicotine, also known as NNN, is a nitrosamine and potential carcinogen found in a variety of tobacco products including snuff, cigarettes, chewing tobacco, and cigars. Certified Spiking Solutions® are suitable for use in nicotine testing or environmental monitoring by LC-MS/MS or GC/MS.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

51.8 °F - closed cup

Punto de inflamabilidad (°C)

11.0 °C - closed cup

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Beibei Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 899, 103-108 (2012-06-01)
N'-nitrosonornicotine (NNN) is a strong carcinogen. The metabolic study of NNN in vivo will help us to further understand it, however, trace detection in complex matrices requires highly sensitive detection methods. After the chromatographic conditions and mass spectrometric conditions had
Ariane Nunes-Alves et al.
Journal of molecular neuroscience : MN, 49(1), 52-61 (2012-08-01)
Nitrosamines are well known for their carcinogenic potential. Recently, it was found that some of them may also interact with human nicotinic acetylcholine receptor (nAChR) subtypes. This work studied the effects of N-nitrosonornicotine (NNN) on recombinant rat α3β4 nAChR in
Irina Stepanov et al.
Cancer research, 69(21), 8236-8240 (2009-10-22)
N'-nitrosonornicotine (NNN) is a strong carcinogen present in unburned tobacco and cigarette smoke. We here analyze data obtained in two studies, in which a biomarker of exposure to NNN--the sum of NNN and its pyridine-N-glucuronide, called total NNN--was quantified in
Gwendolyn A Marriner et al.
The Journal of organic chemistry, 74(7), 2891-2892 (2009-03-11)
A concise and efficient route to (+/-)-N'-nitrosonornicotine 5'-acetate (NNN-5'-OAc), a stable precursor of the active metabolite 5'-hydroxy(+/-)-N'-nitrosonornicotine NNN-5'-OH is reported. The synthesis utilizes sulfinimine chemistry to give (+/-)-NNN-5'-OAc in 26% yield over 4 steps.
Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products.
Stephen S Hecht et al.
Tobacco control, 20(6), 443-443 (2010-10-12)
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