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Merck
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Key Documents

930113

Sigma-Aldrich

NanoFabTx™- COOH Lipid Mix

for synthesis of carboxyl functionalized liposomes

Sinónimos:

for small molecule drug delivery

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

Quality Level

100

storage temp.

−20°C

General description

NanoFabTX™- COOH Lipid Mix; for synthesis of carboxyl functionalized liposomes is a ready-to-use Nano formulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing carboxyl functionalized liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins and peptides. The carboxyl functionalized surface group allows for facile conjugation of targeting groups onto the liposome surface for targeted drug delivery.

Application

About NanoFabTx™

NanoFabTx™ is a collection of ready-to-use drug formulation kits, lipid mixes, and microfluidic device kits for the synthesis of nanocarriers and microcarriers for drug delivery. The kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.

Features and Benefits

  • A ready-to-use Nano formulation lipid blend for the synthesis of carboxyl functionalized liposomes
  • Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Carboxyl surface functionalization allows for targeting ligand conjugation to enable targeted drug delivery
The NanoFabTX™- COOH Lipid Mix provides lipid blends and protocols for extrusion and microfluidics to synthesize liposomes for drug delivery research application. This lipid mix can be combined with the NanoFabTx™ Microfluidic - Nano device kit (Cat.No. 911593) for microfluidic synthesis of carboxyl functionalized liposomes.

Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the document section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Which polymers can make nanoparticulate drug carriers long-circulating?
Torchilin VP, Trubetskoy VS
Advanced Drug Delivery Reviews, 16, 141?155-141?155 (1995)
L D Mayer et al.
Biochimica et biophysica acta, 1025(2), 143-151 (1990-06-27)
Studies from this laboratory (Mayer et al. (1986) Biochim. Biophys. Acta 857, 123-126) have shown that doxorubicin can be accumulated into liposomal systems in response to transmembrane pH gradients (inside acidic). Here, detailed characterizations of the drug uptake and retention
D Papahadjopoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11460-11464 (1991-12-15)
The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect
Yunes Panahi et al.
Artificial cells, nanomedicine, and biotechnology, 45(4), 788-799 (2017-03-11)
Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability;
T D Madden et al.
Chemistry and physics of lipids, 53(1), 37-46 (1990-03-01)
We have shown previously that transmembrane proton gradients can be used to efficiently accumulate biogenic amines [M.B. Bally et al. (1988) Chem. Phys. Lipids 47, 97-107] and doxorubicin [L.D. Mayer, M.B. Bally and P.R. Cullis (1986) Biochim. Biophys. Acta 857
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