926027
NanoFabTX™-DOTAP Lipid Mix
for synthesis of cationic (DOTAP) liposomes
Sinónimos:
Drug delivery, LNP, Microfluidics, NanoFab reagent kit, Nanoformulation, Nanoparticle
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
Productos recomendados
Quality Level
storage temp.
−20°C
General description
NanoFabTx™-DOTAP Lipid Mix includes reagents and optimized protocols with step-by-step instructions for synthesizing cationic liposomes for drug delivery research applications. The modification of liposomes with the cationic lipid, DOTAP, have numerous advantages such as their large-DNA incorporation, high transfection efficiency, and low toxicity. Liposome-based formulations are widely used for drug delivery applications and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins, and peptides.
Comprehensive protocols for liposome synthesis are included:
The microfluidics protocol included with this product uses NanoFabTx™ device kits (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
Comprehensive protocols for liposome synthesis are included:
- A lipid film hydration and extrusion protocol.
- A microfluidics protocol using commercial platforms or syringe pumps.
The microfluidics protocol included with this product uses NanoFabTx™ device kits (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).
Application
NanoFabTx™-DOTAP Lipid Mix is a ready-to-use nanoformulation blend for the synthesis of cationic DOTAP-functionalized liposomes. This kit enables users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
Features and Benefits
- A ready-to-use nanoformulation blend for the synthesis of cationic liposomes
- Step-by-step protocols (extrusion or microfluidic) developed and tested by our formulation scientists
- Flexible synthesis tools to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- DOTAP surface-functionalized allows for targeting ligand conjugation to enable targeted drug delivery
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificados de análisis (COA)
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Which polymers can make nanoparticulate drug carriers long-circulating?
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L D Mayer et al.
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D Papahadjopoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11460-11464 (1991-12-15)
The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect
Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications.
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Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability;
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