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719889

Sigma-Aldrich

Resomer® RG 502, Poli(D,L-Láctido-co-glucólido)

lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000

Sinónimos:

PLGA

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About This Item

Fórmula lineal:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12162002
NACRES:
NA.23

form

amorphous

feed ratio

lactide:glycolide 50:50

mol wt

Mw 7,000-17,000

degradation timeframe

<3 months

viscosity

0.16-0.24 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

transition temp

Tg 42-46 °C

shipped in

wet ice

storage temp.

2-8°C

Application

Resomer® RG 502 puede utilizarse para formular un sistema de administración de nanomedicamentos basado en PLGA para el antiinflamatorio, éter de 6-bromoindirubina-3′-glicerol-oxima (6BIGOE).

También puedeutilizarse para preparar formulaciones de liberación controlada para la administración de HCl de naloxona.

Features and Benefits

  • Biocompatible
  • Biodegradable
  • Puede procesarse en casi cualquier forma y tamaño
  • Propiedades mecánicas ajustables

Legal Information

Producto de Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yung-Hsin Cheng et al.
Experimental eye research, 179, 179-187 (2018-11-25)
Elevated intraocular pressure (IOP) in glaucoma is due to impairment of aqueous humor drainage via the uveoscleral or trabecular outflow pathway. Latanoprost reduces IOP by increasing the uveoscleral outflow. Despite its potency, long-term daily application of it may cause undesirable
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Daniel R Getts et al.
Nature biotechnology, 30(12), 1217-1224 (2012-11-20)
Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce T-cell tolerance have failed. Building on previous strategies for tolerance induction that exploited natural mechanisms for clearing apoptotic debris, we show that antigen-decorated microparticles (500-nm diameter) induce long-term
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
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