X2502

Xanthine sodium salt

≥99%

• Synonyme(s) : 2,6-Dihydroxypurine
• Formule empirique (notation de Hill): C₅H₃N₄NaO₂
• Numéro CAS: 1196-43-6
• Poids moléculaire : 174.09
• Numéro MDL: MFCD00069699
• Code UNSPSC : 41106305
• ID de substance PubChem : 24902137
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Pureté: ≥99%
• Forme: powder
• Impuretés: ≤4% total solvent
• Solubilité: dilute NaOH: soluble, clear to slightly hazy
• Chaîne SMILES: [Na].O=C1NC(=O)c2[nH]cnc2N1
• InChI: 1S/C5H4N4O2.Na.H/c10-4-2-3(7-1-6-2)8-5(11)9-4;;/h1H,(H3,6,7,8,9,10,11);;
• Clé InChI: JAZQMXVZANZJSO-UHFFFAOYSA-N

Description

Description générale

Xanthine is an intermediate of purine nucleotide metabolism. It is found in most body tissues and fluids. Xanthine derivatives are present in coffee, tea, and chocolate.

Application

Xanthine sodium salt has been used as a component of substrate solution for xanthine oxidase during superoxide dismutase (SOD) assay. It has also been used as a supplement in a special-conditioned medium to culture Swiss 3T3 fibroblasts stably transfected with tetracycline (tet)-controlled transactivator and transactivator-controlled tissue transglutaminase cDNA [39] constructs (clone TG3).

Actions biochimiques/physiologiques

Xanthine acts as a substrate for xanthine oxidase. It elevates cellular cyclic AMP levels by preventing its breakdown and metabolism by inhibition of tissue phosphodiesterases. Xanthine also exhibits anti-inflammatory properties either by the release of anti-inflammatory cytokines or gene transcription regulation or histone deacetylase activation. All these properties of xanthine aid in the relaxation of smooth muscles of the bronchial tree.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H371
• Conseils de prudence: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Classification des risques: STOT SE 2
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves