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Principaux documents

M2441

Sigma-Aldrich

Anti-MAGI-2 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-ARIP, Anti-S-SCAM

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat

Technique(s)

microarray: suitable
western blot: 1:250 using rat brain extracts

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

Description générale

MAGI-2 is composed of three domains including six PDZ, one guanylate kinase (GK) and two WW domain.
The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.2

MAGI-2 was initially identified in rat, as a protein interacting with N-methyl-D-aspartate receptors (NMDA-R) and neuronal cell adhesion proteins, and was named S-SCAM.4Three isoforms of S-SCAM were identified, of 1277, 1113 and 1053 amino acids length, respectively.5

Immunogène

synthetic peptide corresponding to amino acids 554-571 of MAGI-2/S-SCAM conjugated to KLH.

Application

Anti-MAGI-2 antibody produced in rabbit has been used in immunoblotting and immunolabeling.

Actions biochimiques/physiologiques

Membrane associated guanylate kinase inverted-2 (MAGI-2) as well as MAGI-3, was shown to interact with the tumor suppressor PTEN through one of its PDZ domains, apparently acting as a scaffolding protein that could assemble a multi subunit signaling complex. It is known to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
Wu X, et al.
Proceedings of the National Academy of Sciences of the USA, 97(8), 4233-4238 (2000)
IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses
Babaev O, et al.
Nature Communications, 9(1), 5400-5400 (2018)
S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors
Danielson E, et al.
The Journal of Neuroscience, 32(20), 6967-6980 (2012)
Olga Babaev et al.
Nature communications, 9(1), 5400-5400 (2018-12-24)
Abnormalities in synaptic inhibition play a critical role in psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of the inhibitory postsynapse to psychiatrically relevant neural circuits and behaviors. Here we study the role of
Bingbing Zhu et al.
Kidney international, 96(3), 642-655 (2019-06-07)
The essential role of membrane associated guanylate kinase 2 (MAGI2) in podocytes is indicated by the phenotypes of severe glomerulosclerosis of both MAGI2 knockout mice and in patients with congenital nephrotic syndrome (CNS) caused by mutations in MAGI2. Here, we

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