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C2538

Sigma-Aldrich

Carboplatin

Synonyme(s) :

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

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About This Item

Formule linéaire :
[C4H6(CO2)2]Pt(NH3)2
Numéro CAS:
41575-94-4
Poids moléculaire :
371.25
Numéro CE :
255-446-0
Numéro MDL:
MFCD00070464
Code UNSPSC :
12352200
ID de substance PubChem :
24278303
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Forme

powder

Niveau de qualité

100

Spectre d'activité de l'antibiotique

neoplastics

Auteur

Bristol-Myers Squibb

Chaîne SMILES 

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

Clé InChI

OLESAACUTLOWQZ-UHFFFAOYSA-L

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Description générale

Carboplatin is used to treat testicular, ovarian and breast cancer.[1]

Application

Carboplatin has been used:
  • in chemotherapy-induced thrombocytopenia mouse model and treatment[2]
  • to induce cell death in a large subset of colorectal cancer cells[3]
  • in the evaluation of cell proliferation and chemosensitivity[4]
  • as a positive control for suppressed cell growth[5]

Actions biochimiques/physiologiques

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
MKCW1333
MKCT7823
MKCR3593
MKCR8746
MKCK1243

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