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Y0001094

Aceclofenac for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Aceclofenac, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;

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About This Item

Formule empirique (notation de Hill):
C16H13Cl2NO4
Numéro CAS:
89796-99-6
Poids moléculaire :
354.18
Numéro MDL:
MFCD00864296
Code UNSPSC :
41116107
ID de substance PubChem :
329831261
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

aceclofenac

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

Clé InChI

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS2(5743)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aceclofenac for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H319,H410

Classification des risques

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Erik Legrand
Expert opinion on pharmacotherapy, 5(6), 1347-1357 (2004-05-28)
Aceclofenac (Almirall Prodesfarma SA) is an oral NSAID that is effective in the treatment of painful inflammatory diseases and has been used to treat > 75 million patients worldwide. It has proved as effective as diclofenac, naproxen and piroxicam in
S S Kulthe et al.
Colloids and surfaces. B, Biointerfaces, 88(2), 691-696 (2011-08-25)
Pluronic block copolymers offer affluent phase behavioral characteristics and are extensively investigated for drug delivery applications. Hydrophobic Pluronics produce larger aggregates whereas hydrophilic Pluronics often generate small-sized micelles in aqueous milieu. To overcome the limitations and combine the advantages of
Jhi-Kai Chang et al.
Clinical rheumatology, 32(3), 341-347 (2012-11-30)
This study aimed to determine the safety and efficacy of tramadol 37.5 mg/acetaminophen 325 mg combination tablets (Ultracet®) in patients with ankylosing spondylitis (AS). This was a 12-week, randomized, double-blind, placebo-controlled study. Sixty patients with active AS according to the
Madhusmruti Khandai et al.
Current drug delivery, 9(5), 495-505 (2012-04-24)
The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to
R Andrew Moore et al.
The Cochrane database of systematic reviews, (3)(3), CD007588-CD007588 (2009-07-10)
Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy
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